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Tag Archives: pathogenposse

Contagious Caturday

I couldn’t resist this picture. Thanks to @EpiRen for tweeting: Someone posted this outside my cube: on Twitpic

Despite being a lifelong non-smoker, in the past few years every single sniffle has degenerated into really nasty acute bronchitis. Therefore I will be getting my ‘flu jab as soon as this season’s batch is ready, with the usual side effect that it may sting a bit because my GP, lovely guy though he is, is bloody awful at doing injections.

That’s the biggest danger you’re likely to run with an influenza vaccination: it doesn’t give you ‘flu, cause autism, ADHD, dyslexia, or whatever. It doesn’t even make you fart uncontrollably during boring speeches, where’s the fun in that? OK, since it’s grown on hen’s eggs it can’t be given to anyone severely allergic to them. If that bothers you, and it probably should, then try donating to research so that a better way of making the vaccines can be found (see Harpocrates Speaks: Putting Your Money Where Your Mouth Is for examples).

However, let’s assume you’re all up to date with your vaccines. Do you have a pet animal? Does it go outside? Did you get it vaccinated as well?

There are some extremely nasty – and expensive – animal diseases going around, most of which can be prevented with a simple annual vaccination. These include respiratory diseases, but also 100% killers like rabies and the feline equivalent of AIDS (FIV), both of which are transmitted through wounds. A cat with FIV has a maximum life expectancy of 5 years, according to my vet. During those 5 years, the animal will require monthly treatment.

If that little ball of fur (or great big floppy-jowled drooling thing, YMMV) is the apple of your eye, make sure its vaccinations are up-to-date. You’ll also be protecting yourself and your family.

If you don’t care enough about your pet to get it vaccinated, you shouldn’t have one.

 
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Posted by on 09/07/2011 in Nature, Vaccination

 

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Shingles and Multiple Sclerosis linked?

A recent study in Taiwan has brought to light a probable link between that extremely nasty and disabling autoimmune disease Multiple Sclerosis, and our old friend Varicella Zoster (which also calls itself Chickenpox or Shingles). Some sort of link had already been suspected between the herpes viruses (a band of microscopic ‘hood thugs which lurk in the nervous system, sneering at passers-by and occasionally going on a rampage) and MS, which is the result of damage to the myelin sheath that protects our nerves and enables them to deliver their electric messages despite Rain, Sleet, or Glom of Nit. However, this is the first study to say: yes, there is.

The trouble is, they can’t yet say what the link is. Does the slow onset of MS (the study took cases that were diagnosed with MS up to a year after the shingles attack) trigger the shingles episode? Or was it shingles that kickstarted the MS? Is V. Zoster the only herpes virus involved, come to that?

Fortunately MS is a very rare disease (especially among Asians, lucky sods). In my life so far, I have met only two people suffering from it. It tends to attack the young, between the ages of 20 and 40. If a causal link can be established to something like V. Zoster for which a vaccine exists (once you’re infected it is incurable, although drugs like acyclovir may help reduce the severity of episodes), this may open the way to more effective treatments and prevention for MS.

Here is the abstract of the published paper (reproduced with permission from the Journal of Infectious Diseases). If you are up to wading through the technical stuff in the study itself, I recommend doing so as it does put the conclusions into perspective as well as suggesting useful areas for future study.

Abstract

Objective.
Varicella zoster virus (VZV) has been proposed to be involved in the pathogenesis of multiple sclerosis (MS). However, the epidemiological data regarding the MS occurrence rate following herpes zoster are still scanty. The goal of this study is to investigate the frequency and risk for MS following occurrence of herpes zoster.

Methods.
This study used the Taiwan National Health Insurance Research Database. A total of 315,550 patients with herpes zoster were included as the study group, and the control group consisted of 946,650 randomly selected subjects. The stratified Cox proportional hazard regression was performed to calculate the 1-year MS-free survival rate.

Results.
Of 1,262,200 sampled patients, 29 from the study group (.009%) and 24 from the control group (.003%) had MS during the 1-year follow-up period. After adjusting for monthly income and geographic region, the hazard of MS was 3.96 times greater (95% CI = 2.22−7.07, p < 0.001) for the study group than controls.

Conclusions.
Our findings support the notion that occurrence of MS could be associated with herpes zoster attack. We found a significantly higher risk for MS within 1 year of herpes zoster attack compared with the control population.

Lastly, just for those who still think chickenpox is a fun childhood disease and only old folks get shingles:

Shingles Returns More Often Than Thought MedicineNet.com

 
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Posted by on 19/06/2011 in Health

 

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